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Fosaprepitant mg IV as a single dose increased the AUC of midazolam given on days 1 and 4 by approximately symptoms and treatment. Less than a 2-fold increase in the midazolam AUC is not considered clinically important.

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Itraconazole is predicted to increase the exposure to encorafenib. Manufacturer advises avoid or monitor. Itraconazole is predicted to increase the exposure to entrectinib.

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Br J Clin Pharmacol. Pharmacokinetics of posaconazole coadministered with antacid in fasting or nonfasting healthy men. AmBisome amphotericin B package insert.

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In general, adverse events reported with overdose have been consistent with adverse drug reactions already listed in this insert for Itraconazole. Itraconazole capsules USP should be taken with a full meal to ensure maximal absorption. Itraconazole capsules USP must be swallowed whole.

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